any thoughts?

I'd say the One is better value being about half the price, although MX-810 can be bought for quite a bit less than the retail price. Programming the MX-810 can be a bitch if you've not done one before.
It's very easy to get the Harmony remotes to do all the basics + in your system, and Harmony has a lot more codes already in it's software to make things quicker for you. To get the Harmony to do more than the basics is still not a big deal, provided you have the time.
I recently got my Harmony (880) to do a macro (one touch operation) for turning my TV speakers on/off for when I just want to watch the news without turning the audio rig on, which pleased me no end. It's amazing how nice it is to be extremely lazy in front of the TV.

I picked the H-1 up last night. Programing will start this evening.

Pioneer HD Panel
Pioneer A/V Receiver - HDMI and Composite for Cable, DHMI for DVD.
Sony Blue Ray
Scientific Atlanta Cable-DVD Box

the tv remote sensor, and if you have zone2 out on your system you can control a separate zone from the same remtoe, or go and buy a 2nd remote for your 2nd zone.

the mx 350 is pretty easy to program but then again I program them all the time.]

why not try programming it and any issues you have you can email me and I will help you get it perfect.

or if you dont like it because of how it looks then get a higher model.

in my eyes theres no need for a fancy remote even for an expensive system. you just need a powerful remote with rf capabilities.

simplicty over rules all. With the ease of programming that the Harmony offers plus the color LCD for all of 249.00, it was a no brainer.

Hey I if I don't like it I do have 30 days to bring it back.

you program it. ill make it setup as a one touch on, one touch off.

up to u just email me!